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EPD (Enzyme Potentiated Desensitization)

Innovative Allergy Vaccine in Pakistan (Enzyme Potentiated Desensitization) or EPD and LAD in USA (Ultra Activated Immuno Therapy)

Dr.Shahid is pioneer in starting this treatment in Pakistan. This is highly effective treatment of different allergies where only one injection is give once every 2-3 months. It is called EPD in UK and Canada while it is called as LAD in USA. EPD is a treatment for allergies developed in the 1960s by Dr. Len McEwen in the United Kingdom. EPD uses much lower doses of antigens than conventional treatment, with the addition of an enzyme, beta glucuronidase. EPD is available in the United Kingdom and Canada for the treatment of hay fever, food allergy and intolerance and environmental allergies. EPD was under development for the treatment of autoimmune disease by a United Kingdom company called Epidyme also owned by Dr. McEwen which has been granted a United Kingdom patent.

Evidence for the Effectiveness of EPD

EPD is considered experimental by some doctors and allergists. However, there is evidence for the efficacy of EPD in the treatment of hay fever and other conditions as a result of nine placebo-controlled, double-blind trials involving 271 patients. These trials showed a significant improvement in the symptoms with probabilities of 0.001 to 0.01 (a chance of one in a thousand to one in a hundred that the results of the trial would be seen by chance alone assuming EPD had no effect). However, one trial involving 183 patients published in the British Medical Journal showed no overall effect.Dr. Len McEwen, inventor of EPD, speculated that the reason for the failure might have been that the beta glucuronidase enzyme preparation was inadvertently heated or frozen during storage in the hospital pharmacy, as it is sensitive to the storage temperature and enzyme from the same manufactured batch had been used to treat a number of patients successfully. However, there is no evidence available after the event to test this theory as the remaining trial materials were destroyed immediately after the trial ended.

Safety of EPD

While the efficacy of EPD is sometimes the subject of controversy among the medical community, the safety of EPD is demonstrated in one study under the control of an Investigational Review Board and reported by the American EPD Society. 5,400 patients received at least 3 doses of EPD with no severe reactions reported. No serious complications have been reported in more than 300,000 doses of EPD given since 1966.

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